Webinar - The International Sepsis Lecture

🎤 Prof. Carolyn Calfee (University of California San Francisco, USA)

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She is a pulmonary/critical care physician-scientist who leads a translational science laboratory and also cares for patients in the medical intensive care unit.  Her group’s research program has three major areas of focus:  (1) molecular phenotyping of ARDS and sepsis, with a particular focus on treatment-responsive phenotypes; (2) Phase I, II and III clinical trials in ARDS, sepsis, and related conditions; and (3) the epidemiology and mechanisms of association between tobacco product use and the development of ARDS.  Her team pioneered the identification of molecular phenotypes in ARDS and sepsis, developing parsimonious models for phenotype identification that are now being implemented in clinical trials, and continues to work to identify key biological differences that characterize these phenotypes in order to inform therapeutic development.

💬 The journey towards individual treatments in sepsis

As clinical, physiological, and biological heterogeneity are becoming more widely recognized and appreciated in sepsis, new approaches to designing precision therapies for specific sepsis subsets are being developed. This talk will review a roadmap to precision therapeutic development in sepsis, using the example of hyperinflammatory and hypoinflammatory phenotypes as well as other examples, and discuss upcoming clinical trial designs that incorporate phenotype-targeted frameworks.

🎤 Prof. Margaret Herridge (University of Toronto, Canada)

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Dr. Herridge is a Professor in the Department of Medicine, a Senior Scientist in the Toronto General Hospital Research Institute and University of Toronto Interdepartmental Division of Critical Care Medicine. She is Director of the CIHR funded national RECOVER ICU Care Continuum Program and the Grace RECOVER Program for Chronic Critical Illness. She is co-lead of CANCOV (Canadian multi-centre 5-year follow-up of patients/caregivers after COVID-19) and is a recognized international content expert on patient and caregiver outcomes after critical illness. She holds a Tier 1 Canada Research Chair in Critical Illness Outcomes and the Recovery Continuum.

💬 Post sepsis syndrome

Overview of post sepsis outcomes for patients, families and the ICU team including:

• Pulmonary Outcomes
• Functional Disability-Muscle Injury and Repair
• Brain Injury, Neurocognition and Mood Disorders
• Similarity/Differences to other Syndromic Constructs - PICS/Frailty/Multimorbidities - Extended PICS
• Lessons from COVID-19

🎤 Prof. Mervyn Singer (University College London, UK)

💬 Assessing organ dysfunction in sepsis

👉 Registration: (to come)
 

🎤 Prof. Bram Rochwerg (McMaster University, Canada)

💬 Surviving Sepsis Campaign guidelines 2026

👉 Registration: (to come)